JCI’s Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stephen O'Rahilly
Professor Stephen O'Rahilly's research has led to an increased understanding of the genetic causes of human obesity and insulin resistance. Using modern ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Michael Hall
Michael N. Hall was recently announced as the recipient of the 2017 Albert Lasker Basic Medical Research Award for the discovery of TOR proteins, which play ...
Journal of Clinical Investigation
JCI's Conversation with Giants in Medicine: Donald Seldin
We are joined by Donald Seldin from The University of Texas Southwestern Medical School. Seldin served as the chairman of medicine at UT Southwestern for ...
Journal of Clinical Investigation
Angiopoietin/Tie2 maintain the flow of Schlemm’s canal
Schlemm's canal is a lymphatic-like vessel in the eye that is critical for proper drainage of aqueous humor. Glaucoma results from increased intraocular pressure ...
Journal of Clinical Investigation
Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: George Church
The geneticist, innovator, and entrepreneur George Church, of Harvard and MIT, developed the methods for the first genome sequencing, and his subsequent ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
Characterizing the cells that underlie breast cancer recurrence
One of the leading factors in breast cancer-related death, is tumor recurrence despite apparently successful therapeutic intervention. Recurrent disease is linked ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Francis Collins
After Francis Collins received his PhD in Physical Chemistry at Yale University and his medical degree at the University of North Carolina, he zeroed in on ...
Journal of Clinical Investigation
The Clinical Investigation Plan
Course Description: Provides the basic information on roles and responsibilities within the process of writing a clinical investigation plan as well as tools for the ...
WMDO
A metabolic approach for retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous genetic disorder that is characterized by a progressive loss of photoreceptors that results in deterioration of vision.
Journal of Clinical Investigation
Kisspeptin receptor agonist and female reproductive disorders
In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Eugene Braunwald
Dr. Eugene Braunwald has often been called the father of modern cardiology. Science Watch has listed Dr. Braunwald as the most frequently cited author in ...
Journal of Clinical Investigation
Understanding the drivers of granulomatosis with polyangiitis
Granulomatosis with polyangiitis (GPA) is a form of autoimmune vasculitis that is associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs) ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
La SRLF et les jeunes chercheurs - Antoine Guillon
En 2018, le Dr Antoine Guillon a été récipiendaire d'une bourse SRLF « Mobilité ». Dans ce cadre, au sein de « The Journal of Clinical Investigation » (JCI ...
SRLF
Kisspeptin in the limbic system
The hormone kisspeptin is essential for reproductive function, an effect that is mediated by its actions in the hypothalamus. Recent studies suggest that ...
Journal of Clinical Investigation
Clinical trial of IL-7 in septic patients
Sepsis is a life-threatening complication of infection that results in over 250000 deaths per year in the United States. There is a strong correlation between ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Christine Seidman
Dr. Christine Seidman of the Harvard Medical School has uncovered the genetic basis of many human cardiovascular disorders, from cardiomyopathy and heart ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Beutler
A legend within the field of innate immunity, Dr. Bruce Beutler of the University of Texas Southwestern Medical School is best known for two seminal discoveries: ...
Journal of Clinical Investigation
Patient Oriented Care in the Medical Sciences in Clinical Investigation Program
Finnian Mc Causland, MBBCh, MMSc, FRCPI, PG CertMedEd, Co-Director of the Master of Medical Sciences in Clinical Investigation (MMSCI) program ...
Harvard Medical School
Predicting atrial fibrillation after ablation
In this episode, Jasmeet Reyat, Winnie Chua, Larissa Fabritz, and colleagues explain that, building on genomic and experimental findings, low PITX2 in left ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
Qualitative Research for Public Health and Clinical Investigation
This video is a one-hour lecture that Roberta E. Goldman, PHD delivered as part of the Harvard Catalyst lecture series in 2011. The lecture presents an overview ...
Brown University
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Dynamic focal adhesions
The accompanying movie shows the effect of targeting different genes on focal adhesion dynamics, which are essential for cell migration. Control and ...
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by ...
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Epigenetic targeting improves metabolic defects in obesity-prone mice
Obesity, diabetes, and other metabolic diseases have known underlying genetic causes; however, environmental factors also play an important role in the onset ...
Journal of Clinical Investigation
Broadly neutralizing HIV-1 antibody identified in a lupus patient
Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
Intracranial hemorrhage development in fetal and neonatal alloimmune thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and ...
Journal of Clinical Investigation
Maternal high-fat diet linked to inflammatory outcomes in offspring
Maternal obesity has been associated with adverse outcomes in offspring; however, it is not clear how maternal obesity or high-fat diet (HFD) impart long-term ...
Journal of Clinical Investigation
