Real-time imaging of intestinal lacteals
Kibaek Choe, Jeon Yeob Jang, Intae Park and colleagues visualize lipid drainage through lacteals using intravital, video-rate microscopy. The first video shows ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Christine Seidman
Dr. Christine Seidman of the Harvard Medical School has uncovered the genetic basis of many human cardiovascular disorders, from cardiomyopathy and heart ...
Journal of Clinical Investigation
CD8+ T cell function may predict type 1 diabetes progression
In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
Journal of Clinical Investigation - Medical Meaning and Pronunciation
https://www.amazon.com/Mosbys-Medical-Dictionary-Mosby/dp/0323414257?&_encoding=UTF8&tag=maturecolors2-20 Journal of Clinical Investigation ...
Medical Dictionary
Mast cell engagement of gamma delta T cells protects against viral infection
The skin is an important barrier to infections and contains resident immune cells poised to respond to pathogens. Tissue-resident mast cells are critical for ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Huda Zoghbi
Dr. Huda Zoghbi is a pediatric neurologist, a Howard Hughes Medical Institute investigator; a professor in the departments of Pediatrics, Molecular and Human ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: George Church
The geneticist, innovator, and entrepreneur George Church, of Harvard and MIT, developed the methods for the first genome sequencing, and his subsequent ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by ...
Journal of Clinical Investigation
JCI Author's Take: Linking dietary sphingolipids to inflammation and intestinal carcinogenesis
Many lines of evidence support a link between prolonged inflammation and tumorigenic transformation. For example, patients with inflammatory bowel disease ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Lloyd Hollingsworth Smith Jr.
Known to most of his friends as Holly, Dr. Lloyd Hollingsworth Smith Jr. joins Ushma Neill, JCI Editor at Large, for the next in the journal's series Conversations ...
Journal of Clinical Investigation
Identification and characterization of GDF6 as a driver of melanoma
Melanoma-directed immunotherapies have improved quality of life and outcome for many patients with this malignancy. Unfortunately, treatment resistance ...
Journal of Clinical Investigation
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is ...
Journal of Clinical Investigation
2020 AAP Presidential Address: Mary E. Klotman, MD
A video version of an article published in the Journal of Clinical Investigation, "2020 Association of American Physicians Presidential Address: Call to arms ...
Journal of Clinical Investigation
AO Clinical Investigation and Documentation in profile
AO Clinical Investigation and Documentation is a full service clinical research organization which runs international multicenter clinical trials from the planning ...
AO Foundation
Intracranial hemorrhage development in fetal and neonatal alloimmune thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: David Nathan
David Nathan, professor at Harvard Medical School and President Emeritus of the Dana-Farber Cancer Institute, is a renowned hematologist with contributions ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Aaron Ciechanover
For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA.
Journal of Clinical Investigation
Angiopoietin/Tie2 maintain the flow of Schlemm’s canal
Schlemm's canal is a lymphatic-like vessel in the eye that is critical for proper drainage of aqueous humor. Glaucoma results from increased intraocular pressure ...
Journal of Clinical Investigation
OX40 signals death for liver-resident immune cells
Invariant natural killer T (iNKT) cells are a prominent component of the liver-resident immune cell population. These cells are involved in both liver regeneration ...
Journal of Clinical Investigation
p21 contributes to macrophage switching during sepsis
During sepsis, there is a progression from a hyperactive immune response to an immunosuppressive state that is characterized by macrophage reprogramming.
Journal of Clinical Investigation
Vascular adhesion protein-1 and liver disease progression
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with metabolic dysfunction. Persistent hepatic inflammation in ...
Journal of Clinical Investigation
Dynamic focal adhesions
The accompanying movie shows the effect of targeting different genes on focal adhesion dynamics, which are essential for cell migration. Control and ...
Journal of Clinical Investigation
Immune tolerance-like pathway inhibits repair following white matter injury
White matter injury is associated with neurological dysfunction in a variety of conditions, ranging from cerebral palsy to vascular dementia. Oligodendrocyte ...
Journal of Clinical Investigation
T cell transmigration through endothelial monolayer
The accompanying movie shows that WT T cells (video 1) are able to transmigrate through an endothelial monolayer, as indicated by the change in phase ...
Journal of Clinical Investigation
Human breast milk-derived commensal limits pathogenic inflammation
Necrotizing enterocolitis is a leading cause of death in preterm infants and is characterized by severe inflammation. The incidence of necrotizing enterocolitis is ...
Journal of Clinical Investigation
Epigenetic targeting improves metabolic defects in obesity-prone mice
Obesity, diabetes, and other metabolic diseases have known underlying genetic causes; however, environmental factors also play an important role in the onset ...
Journal of Clinical Investigation
Image Media Lab and the Journal of Clinical Investigation Partnership
This videos is highlighting 3 years of partnership with the Journal of Clinical Investigation and 26 interviews with the "Giants in Medicine". Since May 2012, the ...
Image Media Lab
Erythrocyte-derived microvesicles induce arterial spasms
In this Episode, Johanne Poisson, Marion Tanguy, Pierre-Emmanuel Rautou, and colleagues discuss that the high prevalence of myocardial infarction without ...
Journal of Clinical Investigation
Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function.
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular ...
Journal of Clinical Investigation
Tripler Army Medical Center, Department of Clinical Investigation
Preparing Medics For The Front Lines. For researchers, scientists and clinicians at Tripler Army Medical Center in Honolulu, it's all about preparing a ready ...
WebsEdgeMedicine
JCI's Conversations with Giants in Medicine: Francis Collins
After Francis Collins received his PhD in Physical Chemistry at Yale University and his medical degree at the University of North Carolina, he zeroed in on ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Don Ganem
After a 15-year focus on the biology of the hepatitis B virus (HBV) family, the modern-day microbe hunter Don Ganem turned his attention to KSHV, the herpes ...
Journal of Clinical Investigation
