JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
Blazing the trail for metastasis
The accompanying movie shows the invasion dynamics of breast cancer spheroids in organotypic culture. Spheroids are composed of trailblazer cells, ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Francis Collins
After Francis Collins received his PhD in Physical Chemistry at Yale University and his medical degree at the University of North Carolina, he zeroed in on ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Michael Hall
Michael N. Hall was recently announced as the recipient of the 2017 Albert Lasker Basic Medical Research Award for the discovery of TOR proteins, which play ...
Journal of Clinical Investigation
Anti-influenza antibody in hemagglutinin head domain interface
In this episode, James Crowe reports a pan-H7 influenza protective human antibody that recognizes an epitope in the hemagglutinin head domain interface and ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Huda Zoghbi
Dr. Huda Zoghbi is a pediatric neurologist, a Howard Hughes Medical Institute investigator; a professor in the departments of Pediatrics, Molecular and Human ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
Tie1 deficiency limits cancer progression and metastasis
As primary tumor progression to metastasis dramatically increases mortality in patients with cancer, strategies to limit tumor cell growth and spread are of great ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Kornfeld
Dr. Stuart Kornfeld is the David C. and Betty Farrell Distinguished Professor of Medicine at Washington University in St. Louis. He is best known for his work ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
Centre for Clinical Investigation and Therapeutics (CCIT)
Centre for Clinical Investigation and Therapeutics (CCIT)
LHSFCanada
Isoquercetin reduces coagulation markers in patients at risk of thrombosis
The release of protein disulfide isomerase (PDI) from cells during disease or in response to injury can exacerbate pathological processes, including ...
Journal of Clinical Investigation
7 Gut Instincts You Should Not Ignore
Have you ever heard the saying follow your gut? Well it's true because no one know you more than you. Gut instinct, or intuition, is your immediate ...
Psych2Go
JCI's Conversations with Giants in Medicine: Elaine Fuchs
Cell biologist Elaine Fuchs of the Rockefeller University is best known for revolutionizing the molecular and genetic study of skin. Her research has shed light on ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Spiegelman
More than almost any other scientist in the field of obesity and metabolism research, the work of Bruce Spiegelman, from the Dana-Farber Cancer Institute and ...
Journal of Clinical Investigation
Potential Method For Treating Scleroderma Uncovered
Researchers have discovered a potential approach for reversing the damage associated with scleroderma. 31 (UPI) -- Researchers at the Hospital for Special ...
Wochit News
Suplementação cardiovascular
Link para se inscrever: https://saudenocoracao.com.br/masterclass/
Victor Sorrentino
Erythrocyte-derived microvesicles induce arterial spasms
In this Episode, Johanne Poisson, Marion Tanguy, Pierre-Emmanuel Rautou, and colleagues discuss that the high prevalence of myocardial infarction without ...
Journal of Clinical Investigation
Kisspeptin in the limbic system
The hormone kisspeptin is essential for reproductive function, an effect that is mediated by its actions in the hypothalamus. Recent studies suggest that ...
Journal of Clinical Investigation
CaMK4 drives podocyte injury
Podocyte dysfunction is a hallmark of kidney injury and occurs in both autoimmune and nonautoimmune renal diseases. Calcium signaling underlies podocyte ...
Journal of Clinical Investigation
Adoptive transfer of EBV-specific T cells in patients with multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS characterized by progressive demyelination and disability. Epstein-Barr (EBV) virus has ...
Journal of Clinical Investigation
Neuroflux sheds light on olfactory sensory neurons
PET allows noninvasive visualization of several physiological, neurochemical, and pharmacological processes within patients. Application of PET in the brain ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
CBD Oil Health Benefits. for Anxiety, Pain, Sleep and Side Effects
CBD Oil Health Benefits.CBD Oil Health Benefits, CBD Cannabidiol Hemp Oil Vape Health Benefits for Anxiety, Pain, Sleep and Side Effects | What is CBD Oil?
Health and Wellbeing
John Ioannidis - "lockdown is a nuclear weapon that destroys everything"
C.F. Rehnborg Chair in Disease Prevention, Professor of Medicine, of Epidemiology and Population Health, and (by courtesy) of Biomedical Data Science, and ...
Co-Immunity
Poly(A)-specific ribonuclease deficiency in patients with dyskeratosis congenita
The inherited disorder dyskeratosis congenita is characterized by short telomeres, mucocutaneous abnormalities, and bone marrow failure. The underlying ...
Journal of Clinical Investigation
CD163+ macrophages serve pathogenic role in atherosclerosis
Macrophage polarization in response to stimuli within the microenvironment results in heterogeneous populations that can differentially influence disease.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Christine Seidman
Dr. Christine Seidman of the Harvard Medical School has uncovered the genetic basis of many human cardiovascular disorders, from cardiomyopathy and heart ...
Journal of Clinical Investigation
MedUni Wien RoM März 2020: Selma Osmanagic-Myers
Blutgefäßalterung und kardiovaskuläre Erkrankungen MedUni Wien RESEARCHER OF THE MONTH, März 2020 Die Jury „Researcher of the Month” verleiht ...
MedUni Wien
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular ...
Journal of Clinical Investigation
Urinary markers of acute interstitial nephritis
In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis…
Journal of Clinical Investigation
MICAL1 constrains and protects against disease by oxidizing CaMKII
In this episode, Mark Anderson explains that the stereospecific redox status of CaMKII Methionine 308 regulates CaMKII activation and determines physiological ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Don Ganem
After a 15-year focus on the biology of the hepatitis B virus (HBV) family, the modern-day microbe hunter Don Ganem turned his attention to KSHV, the herpes ...
Journal of Clinical Investigation
Twenty-six compelling conversations
Since May 2012, the JCI has aired twenty-six interviews with twenty-eight notable scientists for the series Conversations with Giants in Medicine. In the highlight ...
Journal of Clinical Investigation
