Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
The Clinical Investigation Plan
Course Description: Provides the basic information on roles and responsibilities within the process of writing a clinical investigation plan as well as tools for the ...
WMDO
Angiopoietin/Tie2 maintain the flow of Schlemm’s canal
Schlemm's canal is a lymphatic-like vessel in the eye that is critical for proper drainage of aqueous humor. Glaucoma results from increased intraocular pressure ...
Journal of Clinical Investigation
Стимуляция поясного пучка при операции на мозге в состоянии бодрствования
Credits: Kelly Bjanki et al. / The Journal of Clinical Investigation, 2019.
Nplus1
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Francis Collins
After Francis Collins received his PhD in Physical Chemistry at Yale University and his medical degree at the University of North Carolina, he zeroed in on ...
Journal of Clinical Investigation
Journal of Clinical Investigation spanish MEANING
TOP LIST HERE: https://www.youtube.com/playlist?list=PLwTXvKHGHam46KJ_waPqG5PPapwi4iz3K Simple Way for people who understand spanish, to know ...
TOP SPANISH BEST EXPLAINED LEVEL 10
AO Clinical Investigation and Documentation in profile
AO Clinical Investigation and Documentation is a full service clinical research organization which runs international multicenter clinical trials from the planning ...
AO Foundation
Creating and publishing a scientific masterpiece
JCI Editor at Large Ushma S. Neill provides updated advice on generating a scientific manuscript with maximum impact.
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
Qualitative Research for Public Health and Clinical Investigation
This video is a one-hour lecture that Roberta E. Goldman, PHD delivered as part of the Harvard Catalyst lecture series in 2011. The lecture presents an overview ...
Brown University
JCI's Conversations with Giants in Medicine: Eugene Braunwald
Dr. Eugene Braunwald has often been called the father of modern cardiology. Science Watch has listed Dr. Braunwald as the most frequently cited author in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: David Nathan
David Nathan, professor at Harvard Medical School and President Emeritus of the Dana-Farber Cancer Institute, is a renowned hematologist with contributions ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stephen O'Rahilly
Professor Stephen O'Rahilly's research has led to an increased understanding of the genetic causes of human obesity and insulin resistance. Using modern ...
Journal of Clinical Investigation
REG3α as a biomarker and therapeutic target for GVHD
Graft-versus-host-disease (GVHD) is a life-threatening complication of allogeneic BM transplantation that affects skin, liver, and the gastrointestinal (GI) tract.
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is ...
Journal of Clinical Investigation
JAK inhibitor treatment shows benefit for patients with interferonopathies
Patients with IFN-mediated autoinflammatory diseases, such as CANDLE and SAVI, present with a variety of severe manifestations, including fever and ...
Journal of Clinical Investigation
Format and Structure of a Medical Device Clinical Investigation Plan/Protocol
Course Description: This course provides an in-depth review of the contents and format of a clinical investigation plan according to ISO 14155 and 21 CRF part ...
WMDO
JCI's Conversations with Giants in Medicine: Michael Hall
Michael N. Hall was recently announced as the recipient of the 2017 Albert Lasker Basic Medical Research Award for the discovery of TOR proteins, which play ...
Journal of Clinical Investigation
Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function.
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Lucy Shapiro
Lucy Shapiro, of Stanford University, is a renowned molecular and developmental biologist whose work has answered the fundamental questions underlying the ...
Journal of Clinical Investigation
JCI's Conversation with Giants in Medicine: Donald Seldin
We are joined by Donald Seldin from The University of Texas Southwestern Medical School. Seldin served as the chairman of medicine at UT Southwestern for ...
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: James Allison
James Allison of the MD Anderson Cancer Center has made key discoveries on the regulation of T cell activation and modulation, including identification and ...
Journal of Clinical Investigation
CD163+ macrophages serve pathogenic role in atherosclerosis
Macrophage polarization in response to stimuli within the microenvironment results in heterogeneous populations that can differentially influence disease.
Journal of Clinical Investigation
Application of adult-derived human satellite cells
Muscle satellite cells are a rare regenerative population in adult skeletal muscle and have potential to repair damaged muscle tissue. In this episode, Simone ...
Journal of Clinical Investigation
Murine model of autism-like syndrome benefits from NAP treatment
Activity-dependent neuroprotective protein (ADNP) is essential for brain formation, and mutations in the ADNP-encoding gene have been linked to an ...
Journal of Clinical Investigation
Identification and characterization of GDF6 as a driver of melanoma
Melanoma-directed immunotherapies have improved quality of life and outcome for many patients with this malignancy. Unfortunately, treatment resistance ...
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Don Ganem
After a 15-year focus on the biology of the hepatitis B virus (HBV) family, the modern-day microbe hunter Don Ganem turned his attention to KSHV, the herpes ...
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by ...
Journal of Clinical Investigation
JCI"s Conversations with Giants in Medicine: Rudolf Jaenisch
JCI Editor-at-Large Ushma Neill interviews Rudolf Jaenisch of MIT's Whitehead Institute. Dr. Jaenisch created the first transgenic mice and conducted the first ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Aaron Ciechanover
For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Spiegelman
More than almost any other scientist in the field of obesity and metabolism research, the work of Bruce Spiegelman, from the Dana-Farber Cancer Institute and ...
Journal of Clinical Investigation
Innovations in Treatment | #FrontlineLessons From the Epicenter of the Pandemic
Located in the center of the COVID-19 pandemic in the Bronx, New York, Montefiore experts have invaluable insight into lessons learned from the frontlines to ...
Montefiore Health System
Twenty-six compelling conversations
Since May 2012, the JCI has aired twenty-six interviews with twenty-eight notable scientists for the series Conversations with Giants in Medicine. In the highlight ...
Journal of Clinical Investigation
Immune tolerance-like pathway inhibits repair following white matter injury
White matter injury is associated with neurological dysfunction in a variety of conditions, ranging from cerebral palsy to vascular dementia. Oligodendrocyte ...
Journal of Clinical Investigation
2020 AAP Presidential Address: Mary E. Klotman, MD
A video version of an article published in the Journal of Clinical Investigation, "2020 Association of American Physicians Presidential Address: Call to arms ...
Journal of Clinical Investigation
JCI Author's Take: Linking dietary sphingolipids to inflammation and intestinal carcinogenesis
Many lines of evidence support a link between prolonged inflammation and tumorigenic transformation. For example, patients with inflammatory bowel disease ...
Journal of Clinical Investigation
