JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
Vaginal epithelial shedding mediates ascending group B streptococcus infection
Group B streptococcus (GBS) is part of the normal vaginal flora of approximately 25% of healthy women. Unfortunately, GBS is associated with adverse ...
Journal of Clinical Investigation
Characterization of FOXN1 mutation-mediated immune deficiency
In this episode, Nicolai van Oers and colleagues demonstrate that compound heterozygous mutations in FOXN1 result in a combined immunodeficiency in ...
Journal of Clinical Investigation
Sphingolipid desaturase DEGS1 linked to rare leukodystrophy
Leukodystrophies are rare congenital disorders that affect the white matter of the brain, resulting in a range of neurological presentations. Several ...
Journal of Clinical Investigation
Application of adult-derived human satellite cells
Muscle satellite cells are a rare regenerative population in adult skeletal muscle and have potential to repair damaged muscle tissue. In this episode, Simone ...
Journal of Clinical Investigation
Good Clinical Practice (Lecture-48)
ignousohs
JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
Altered abiraterone metabolism in individuals with HSD3B1 variant
Prostate cancer is driven by stimulation of the androgen receptor (AR) with testosterone and the potent metabolite 5α-dihydrotestosterone (DHT); therefore, ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
Broadly neutralizing HIV-1 antibody identified in a lupus patient
Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved ...
Journal of Clinical Investigation
CD163+ macrophages serve pathogenic role in atherosclerosis
Macrophage polarization in response to stimuli within the microenvironment results in heterogeneous populations that can differentially influence disease.
Journal of Clinical Investigation
New Strategies for Clinical Trials in Autism Spectrum Disorder
New Strategies for Clinical Trials in Autism Spectrum Disorder Web: https://www.eurekaselect.com/188213/article Author(s): Rini Pauly, Catherine A. Ziats, ...
Bentham Science
Vaccine targeting protects macaques against vaginal infection
In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates ...
Journal of Clinical Investigation
Murine model of autism-like syndrome benefits from NAP treatment
Activity-dependent neuroprotective protein (ADNP) is essential for brain formation, and mutations in the ADNP-encoding gene have been linked to an ...
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
Insight into lupus-associated CD11b mutations
Individuals with mutations in the gene encoding the CD11b are at high risk of developing the autoimmune disease systemic lupus erythematosus (SLE). In this ...
Journal of Clinical Investigation
Unraveling profibrotic pathways in the kidney
Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation ...
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Blazing the trail for metastasis
The accompanying movie shows the invasion dynamics of breast cancer spheroids in organotypic culture. Spheroids are composed of trailblazer cells, ...
Journal of Clinical Investigation
Compound delivers a one-two punch to target cancer metabolism
Cancer cells have a different response to nutrient limitation than healthy cells; therefore, targeting nutrient acquisition pathways has potential as a therapeutic ...
Journal of Clinical Investigation
REG3α as a biomarker and therapeutic target for GVHD
Graft-versus-host-disease (GVHD) is a life-threatening complication of allogeneic BM transplantation that affects skin, liver, and the gastrointestinal (GI) tract.
Journal of Clinical Investigation
Clinical Trials Medical Device & Drug Development Education Planning Session
We will also provide you with current options for financial assistance, career planning resources, and supply you with the courses within our Clinical Trials ...
UCI Division of Continuing Education
Opinion on MRD in CLL: routine use or clinical trials?
Measurable residual disease (MRD) is moving into the clinical setting, attracting varying opinions on the method and setting of its use. Here. Kanti Rai, MD, of ...
VJHemOnc – Video Journal of Hematological Oncology
An Introduction to Clinical Trials: The Global Health Network
George Warimwe, the Kenya Medical Research Institute (KEMRI)/Wellcome Trust Research Programme, Kilifi, Kenya talks about clinical trials.
The Global Health Network
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
Altered T cell metabolism and dysregulated cytokine associations in ME/CFS
A new Journal of Clinical Investigation publication dives into immune dysregulation in ME/CFS. This video by recent ENID Center researcher and Hanson Lab ...
Cornell Center for Enervating NeuroImmune Disease
Epigenetic targeting improves metabolic defects in obesity-prone mice
Obesity, diabetes, and other metabolic diseases have known underlying genetic causes; however, environmental factors also play an important role in the onset ...
Journal of Clinical Investigation
Pinpointing epidemic group A Streptococcus strain emergence
Group A Streptococcus (GAS) causes a wide array of infections ranging from mild to serious and even life threatening. Epidemic strains of GAS have enhanced ...
Journal of Clinical Investigation
Clinical trial evaluates R. mucosa for atopic dermatitis
The inflammatory skin disease atopic dermatitis is characterized by decreased epidermal barrier function, susceptibility to S. aureus infection, and immune ...
Journal of Clinical Investigation
Increased brain uptake and oxidation of acetate in heavy drinkers
Graeme Mason of Yale University discusses how heavy drinking influences metabolism and leads to alternate fuel use in the brain. Highlights: • Brain acetate ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
Immune tolerance-like pathway inhibits repair following white matter injury
White matter injury is associated with neurological dysfunction in a variety of conditions, ranging from cerebral palsy to vascular dementia. Oligodendrocyte ...
Journal of Clinical Investigation
β-globin gene transfer in human bone marrow for sickle cell disease
In this episode of JCI's Author's Take, Donald Kohn of UCLA describes his group's efforts to develop a method to safely and effectively modify patient bone ...
Journal of Clinical Investigation
Vascular adhesion protein-1 and liver disease progression
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with metabolic dysfunction. Persistent hepatic inflammation in ...
Journal of Clinical Investigation
Addressing the point of no return for gene therapy
Retinitis pigmentosa (RP) is hereditary retinal degenerative disease that is characterized by progressive loss of photoreceptor function. In human trials, gene ...
Journal of Clinical Investigation
UK Study Finds Potential New Drug Target for Lung Cancer
Led by University of Kentucky Markey Cancer Center researcher Teresa Fan and published in the Journal of Clinical Investigation, a new study suggests that ...
University of Kentucky
Donor tissue-derived exosomes may predict transplant rejection
Immune-mediated rejection of donor tissues is one of the largest challenges in transplant biology. While routine biopsy to monitor transplanted organs can be ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Napoleone Ferrara
Napoleone Ferrara, of the University of California, San Diego, is best known for isolating and cloning vascular endothelial growth factor (VEGF). He then built the ...
Journal of Clinical Investigation
