JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Tony Fauci
Tony Fauci is the Director of the National Institute of Allergy and Infectious Diseases within the NIH. His work on HIV is at the forefront of infectious disease ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann
Sir Marc Feldmann's research over the last 30 years has focused on the understanding of autoimmune disease, specifically the treatment of rheumatoid arthritis ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Beutler
A legend within the field of innate immunity, Dr. Bruce Beutler of the University of Texas Southwestern Medical School is best known for two seminal discoveries: ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Carla Shatz
Neurobiologist Carla Shatz, director of Stanford University Bio-X, has focused her research on how early brain circuits are transformed into adult connections ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Griffin Rodgers
Beginning in the mid-1980s, Dr. Griffin Rodgers, Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Elaine Fuchs
Cell biologist Elaine Fuchs of the Rockefeller University is best known for revolutionizing the molecular and genetic study of skin. Her research has shed light on ...
Journal of Clinical Investigation
JCI Author's Take: A murine model of JC virus infection
The rare demyelinating disorder progressive multifocal leukoencephalopathy is triggered by JC virus infection of glial cells. Current models to study JC virus ...
Journal of Clinical Investigation
Stacie Bloom on Building a Professional Network in a Science Career
In Chapter 12 of 19 in her 2011 Capture Your Flag interview with host Erik Michielsen, Stacie Grossman Bloom answers "How Did You Turn Extensive Travel as ...
Capture Your Flag
REV-ERBα controls the clock in the lung
There is a strong variation in pulmonary inflammation depending on the time of day. Airway epithelial cells have been shown to mediate rhythmic inflammatory ...
Journal of Clinical Investigation
The COVID-19 immune landscape correlation with disease severity
In this episode, Jane Buckner explains a longitudinal analysis of acute COVID-19 ranging from mild to severe disease determining immune trajectories of ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Douglas R. Lowy and John T. Schiller
The combined efforts of Doug Lowy and John Schiller form the basis of the biology behind the vaccines for HPV (human papillomavirus), which underlies ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Südhof
The simple fact that you can understand the words on this page, and that you might remember any of this interview tomorrow, is thanks to the simultaneous and ...
Journal of Clinical Investigation
Inflammation of the heart after reperfused myocardial infarction
In this issue, Edward Thorp explains that AXL uniquely promotes a switch to glycolytic metabolism and inflammatory cytokine production by macrophages to ...
Journal of Clinical Investigation
Microenvironmental Th9 and Th17 induce spreading in lung cancer
In this episode, Rajkumar Savai and colleagues explain that Th9 and Th17 lymphocytes induce lung cancer cell epithelial-mesenchymal transition via release of ...
Journal of Clinical Investigation
Pancreatic triglyceride lipase mediates lipotoxic systemic inflammation
In this episode, Vijay Singh and colleagues reveal that Pancreatic lipase-mediated necrosis of visceral fat worsens outcomes in acute pancreatitis.
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Lucy Shapiro
Lucy Shapiro, of Stanford University, is a renowned molecular and developmental biologist whose work has answered the fundamental questions underlying the ...
Journal of Clinical Investigation
臺大醫院研究團隊發表突破性成果「調控腎臟細胞的記憶可以防止 急性腎損傷進展至慢性腎臟病」於國際知名期刊 The Journal of Clinical Investigation
臺大醫院NTUHospital
JCI's Conversations with Giants in Medicine: Eugene Braunwald
Dr. Eugene Braunwald has often been called the father of modern cardiology. Science Watch has listed Dr. Braunwald as the most frequently cited author in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Helen Hobbs
Helen Hobbs is an investigator of the Howard Hughes Medical Institute and a professor of Internal Medicine and Molecular Genetics at the University of Texas ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Spiegelman
More than almost any other scientist in the field of obesity and metabolism research, the work of Bruce Spiegelman, from the Dana-Farber Cancer Institute and ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Laurie Glimcher
Laurie Glimcher is a world-class immunologist who discovered the master transcription factors that direct immune cells to commit and activate. She has also ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: David Nathan
David Nathan, professor at Harvard Medical School and President Emeritus of the Dana-Farber Cancer Institute, is a renowned hematologist with contributions ...
Journal of Clinical Investigation
AO Clinical Investigation and Documentation in profile
AO Clinical Investigation and Documentation is a full service clinical research organization which runs international multicenter clinical trials from the planning ...
AO Foundation
MICAL1 constrains and protects against disease by oxidizing CaMKII
In this episode, Mark Anderson explains that the stereospecific redox status of CaMKII Methionine 308 regulates CaMKII activation and determines physiological ...
Journal of Clinical Investigation
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis
Jane Salmon, Carl Blobel, Priya Darshinee Issuree, and Thorsten Maretzky of the Weill Cornell University Hospital for Special Surgery discuss the role of ...
Journal of Clinical Investigation
Maintenance DNA methylation is essential for development and stability
In this episode, Benjamin Singer and colleagues explain that maintenance DNA methylation at inflammatory gene loci is necessary to stabilize regulatory T cell ...
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by ...
Journal of Clinical Investigation
The TGR5 receptor mediates bile acid-induced itch and analgesia
The liver secretes bile acids to aid in the digestion of fats. Cholestasis is a condition in which the bile flow from the liver to the duodenum is impeded. Patients ...
Journal of Clinical Investigation
Centre for Clinical Investigation and Therapeutics (CCIT)
Centre for Clinical Investigation and Therapeutics (CCIT)
LHSFCanada
Inner blood-retina barrier dysfunction linked to retina cell loss
In this episode, Matthew Campbell, Natalie Hudson, and colleagues show that blood vessels of the inner retina are highly dynamic and that loss of inner ...
Journal of Clinical Investigation
JAK inhibitor treatment shows benefit for patients with interferonopathies
Patients with IFN-mediated autoinflammatory diseases, such as CANDLE and SAVI, present with a variety of severe manifestations, including fever and ...
Journal of Clinical Investigation
Munc18 isoforms play distinct roles in airway mucin secretion
Precise control of airway mucin secretion is essential for maintaining proper lung function. In this episode, Burton Dickey, Ana Jaramillo, and colleagues ...
Journal of Clinical Investigation