JCI’s Conversations with Giants in Medicine: Peter Agre
After a 20-year focus on the water channel aquaporin (work for which he shared the 2003 Nobel Prize in Chemistry), Peter Agre has turned his attention to ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Griffin Rodgers
Beginning in the mid-1980s, Dr. Griffin Rodgers, Director of the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) at the National ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Lucy Shapiro
Lucy Shapiro, of Stanford University, is a renowned molecular and developmental biologist whose work has answered the fundamental questions underlying the ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Elaine Fuchs
Cell biologist Elaine Fuchs of the Rockefeller University is best known for revolutionizing the molecular and genetic study of skin. Her research has shed light on ...
Journal of Clinical Investigation
A pharmacological approach to reversing aniridia
Nonsense mutations that lead to PAX6 haploinsufficiency cause congenital aniridia, a panocular condition that results in severe vision defects. Cheryl ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bonnie Bassler
Bonnie Bassler of Princeton University and the Howard Hughes Medical Institute has revolutionized the way that we think about microbiology. She elucidated ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
Creating and publishing a scientific masterpiece
JCI Editor at Large Ushma S. Neill provides updated advice on generating a scientific manuscript with maximum impact.
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Kisspeptin receptor agonist and female reproductive disorders
In this episode, Ali Abbara and colleagues discuss that the Kisspeptin receptor agonist, MVT-602, has greater potency and longer duration of action than native ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
Clinical trials of non-chemotherapy-containing therapies by the German CLL Study Group
At the 20th Congress of the European Hematology Association (EHA), Barbara Eichhorst, MD, of the University of Cologne, Cologne, Germany, summarises ...
VJHemOnc – Video Journal of Hematological Oncology
Clinical Trials: Why Are They Important and Why Should I Participate? Dinesh Khanna, M.D., M.S.-2017
In this session, the speaker will discuss the importance of participating in clinical trials and how to interpret them. Specifically, you will learn different phases of ...
Scleroderma Foundation
JCI's Conversations with Giants in Medicine: Bruce Alberts
Though Bruce Alberts is well known for his work on the biochemistry of DNA replication and as the editor-in-chief of Science, he is also recognizable as the ...
Journal of Clinical Investigation
JCI Conversations with Giants in Medicine: Bert Vogelstein and Kenneth Kinzler
Bert Vogelstein, MD, and Kenneth Kinzler, PhD, are codirectors of the Ludwig Center at the Sidney Kimmel Comprehensive Cancer Center of the Johns Hopkins ...
Journal of Clinical Investigation
A biomarker signature of treatment-resistant HPV-related cancer
Human papilloma virus (HPV) is an etiological agent of oropharyngeal squamous cell carcinoma (OPSCC). Patients with HPV+ OPSCC have high long-term ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Huda Zoghbi
Dr. Huda Zoghbi is a pediatric neurologist, a Howard Hughes Medical Institute investigator; a professor in the departments of Pediatrics, Molecular and Human ...
Journal of Clinical Investigation
Application of adult-derived human satellite cells
Muscle satellite cells are a rare regenerative population in adult skeletal muscle and have potential to repair damaged muscle tissue. In this episode, Simone ...
Journal of Clinical Investigation
A role for plasminogen activator inhibitor type 1 in skin fibrosis
Fibrosis is a characterized by excessive extracellular matrix deposition, resulting in tissue damage and loss of function. Activated fibroblasts are responsible for ...
Journal of Clinical Investigation
Secondary insult reveals etiology of GATA2 enhancer mutation-associated blood disorder
The transcription factor GATA-2 is critical regulator of hematopoietic stem and progenitor cell (HSPC) development and function, and mutations in the enhancer ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
Clinical trial of IL-7 in septic patients
Sepsis is a life-threatening complication of infection that results in over 250000 deaths per year in the United States. There is a strong correlation between ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Eugene Braunwald
Dr. Eugene Braunwald has often been called the father of modern cardiology. Science Watch has listed Dr. Braunwald as the most frequently cited author in ...
Journal of Clinical Investigation
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Helene Benveniste of Stony Brook University discusses the use of contrast-enhanced MRI to visualize the glymphatic system, a paravascular pathway that ...
Journal of Clinical Investigation
JAK inhibitor treatment shows benefit for patients with interferonopathies
Patients with IFN-mediated autoinflammatory diseases, such as CANDLE and SAVI, present with a variety of severe manifestations, including fever and ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Beutler
A legend within the field of innate immunity, Dr. Bruce Beutler of the University of Texas Southwestern Medical School is best known for two seminal discoveries: ...
Journal of Clinical Investigation
Tie1 deficiency limits cancer progression and metastasis
As primary tumor progression to metastasis dramatically increases mortality in patients with cancer, strategies to limit tumor cell growth and spread are of great ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Helen Hobbs
Helen Hobbs is an investigator of the Howard Hughes Medical Institute and a professor of Internal Medicine and Molecular Genetics at the University of Texas ...
Journal of Clinical Investigation
Mifepristone treatment of alcohol-dependent rats and humans
Alcohol abuse is a major risk factor for morbidity and disability throughout the world, and treatment options are limited for this complex psychiatric condition.
Journal of Clinical Investigation
TLR9 activation in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is the most common liver disease in the US and can lead to cirrhosis, cancer, and death; however, the drivers of NASH ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Frataxin deficiency and pulmonary hypertension
In this episode, Stephen Chan explains that genetic and acquired frataxin deficiency disrupts genomic integrity to induce endothelial senescence and represents ...
Journal of Clinical Investigation
Understanding the drivers of granulomatosis with polyangiitis
Granulomatosis with polyangiitis (GPA) is a form of autoimmune vasculitis that is associated with the presence of anti-neutrophil cytoplasmic antibodies (ANCAs) ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann
Sir Marc Feldmann's research over the last 30 years has focused on the understanding of autoimmune disease, specifically the treatment of rheumatoid arthritis ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Laurie Glimcher
Laurie Glimcher is a world-class immunologist who discovered the master transcription factors that direct immune cells to commit and activate. She has also ...
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Microenvironmental Th9 and Th17 induce spreading in lung cancer
In this episode, Rajkumar Savai and colleagues explain that Th9 and Th17 lymphocytes induce lung cancer cell epithelial-mesenchymal transition via release of ...
Journal of Clinical Investigation
JCI Author's Take: A murine model of JC virus infection
The rare demyelinating disorder progressive multifocal leukoencephalopathy is triggered by JC virus infection of glial cells. Current models to study JC virus ...
Journal of Clinical Investigation
