Beige Area Detection Software : Journal of Clinical Investigation : JCI 125646
This Software is published as a part of research article https://www.jci.org/articles/view/125646 in Journal of Clinical Investigation title: Breast milk alkylglycerols ...
Gopal Karemore
Using proteomics to predict heart disease risk
Atherosclerosis can result in severe outcomes, including heart attack and stroke. The presence of atherosclerotic plaques is one of the first signs of disease; ...
Journal of Clinical Investigation
N173W Research Video: FASD
All credit goes toward the original research. Weeks, 2020, Fetal alcohol spectrum disorder predisposes to metabolic abnormalities in adulthood, The Journal of ...
Chathuri Gunasekera
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
REG3α as a biomarker and therapeutic target for GVHD
Graft-versus-host-disease (GVHD) is a life-threatening complication of allogeneic BM transplantation that affects skin, liver, and the gastrointestinal (GI) tract.
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
TRPV4 channels are essential for protection from lung edema
In this episode, Alexander Dietrich and Christian Schremmer explain how TRPV4 is essential for alveolar epithelial function and protects from ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Broadly neutralizing HIV-1 antibody identified in a lupus patient
Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
Intracranial hemorrhage development in fetal and neonatal alloimmune thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
Poly(A)-specific ribonuclease deficiency in patients with dyskeratosis congenita
The inherited disorder dyskeratosis congenita is characterized by short telomeres, mucocutaneous abnormalities, and bone marrow failure. The underlying ...
Journal of Clinical Investigation
Increased cardiomyocyte proliferation benefit depends on the heart injury
Pathogenic remodeling following heart injury is due, in part, to the limited regenerative capacity of adult cardiomyocytes. Cell cycle induction has been recently ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
Overactive microglia in the aging brain
Not only neurons exist in the brain, but also immune cells, the microglia. These microglia form our "brain security" and protect the brain from pathogens. But with ...
DZNE
JCI"s Conversations with Giants in Medicine: Rudolf Jaenisch
JCI Editor-at-Large Ushma Neill interviews Rudolf Jaenisch of MIT's Whitehead Institute. Dr. Jaenisch created the first transgenic mice and conducted the first ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Lucy Shapiro
Lucy Shapiro, of Stanford University, is a renowned molecular and developmental biologist whose work has answered the fundamental questions underlying the ...
Journal of Clinical Investigation
Adoptive transfer of EBV-specific T cells in patients with multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS characterized by progressive demyelination and disability. Epstein-Barr (EBV) virus has ...
Journal of Clinical Investigation
Urinary markers of acute interstitial nephritis
In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis…
Journal of Clinical Investigation
Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function.
Journal of Clinical Investigation
How to Do a Keto Diet: The Complete Guide
Please hit that red SUBSCRIBE button! Get Groceries DELIVERED with Thrive! http://ThriveMarket.com/Thomas Also check out all my keto & fasting essentials ...
Thomas DeLauer
Vascular adhesion protein-1 and liver disease progression
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with metabolic dysfunction. Persistent hepatic inflammation in ...
Journal of Clinical Investigation
La SRLF et les jeunes chercheurs - Antoine Guillon
En 2018, le Dr Antoine Guillon a été récipiendaire d'une bourse SRLF « Mobilité ». Dans ce cadre, au sein de « The Journal of Clinical Investigation » (JCI ...
SRLF
Unraveling the role of sex in renal ischemia tolerance
Sex-specific differences have been observed in preclinical models of renal ischemic injury. In particular, females recover more readily from ischemia-reperfusion ...
Journal of Clinical Investigation
Unraveling profibrotic pathways in the kidney
Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
Isoquercetin reduces coagulation markers in patients at risk of thrombosis
The release of protein disulfide isomerase (PDI) from cells during disease or in response to injury can exacerbate pathological processes, including ...
Journal of Clinical Investigation
Clinical trial evaluates R. mucosa for atopic dermatitis
The inflammatory skin disease atopic dermatitis is characterized by decreased epidermal barrier function, susceptibility to S. aureus infection, and immune ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the ...
Journal of Clinical Investigation
Centre for Clinical Investigation and Therapeutics (CCIT)
Centre for Clinical Investigation and Therapeutics (CCIT)
LHSFCanada
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
MedUni Wien - RoM | März 2020: Selma Osmanagic-Myers
Blutgefäßalterung und kardiovaskuläre Erkrankungen MedUni Wien RESEARCHER OF THE MONTH, März 2020 Die Jury „Researcher of the Month” verleiht ...
MedUni Wien
The Swedish Strategy - Not Just a Failure
Life in Sweden is closer to being 'normal' than in most other countries. Calling it a success or failure at this stage, however, is premature. Join my channel and ...
The Hated One
OX40 signals death for liver-resident immune cells
Invariant natural killer T (iNKT) cells are a prominent component of the liver-resident immune cell population. These cells are involved in both liver regeneration ...
Journal of Clinical Investigation
Increased brain uptake and oxidation of acetate in heavy drinkers
Graeme Mason of Yale University discusses how heavy drinking influences metabolism and leads to alternate fuel use in the brain. Highlights: • Brain acetate ...
Journal of Clinical Investigation
JCI Conversations with Giants in Medicine: Bert Vogelstein and Kenneth Kinzler
Bert Vogelstein, MD, and Kenneth Kinzler, PhD, are codirectors of the Ludwig Center at the Sidney Kimmel Comprehensive Cancer Center of the Johns Hopkins ...
Journal of Clinical Investigation
Blood type A people may be more likely to get traveler's diarrhea
For story suggestions or custom animation requests, contact tips@nextanimation.com.tw. Visit http://archive.nextanimationstudio.com to view News Direct's ...
News Direct
JCI's Conversations with Giants in Medicine: Bruce Alberts
Though Bruce Alberts is well known for his work on the biochemistry of DNA replication and as the editor-in-chief of Science, he is also recognizable as the ...
Journal of Clinical Investigation
Immune tolerance-like pathway inhibits repair following white matter injury
White matter injury is associated with neurological dysfunction in a variety of conditions, ranging from cerebral palsy to vascular dementia. Oligodendrocyte ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Spiegelman
More than almost any other scientist in the field of obesity and metabolism research, the work of Bruce Spiegelman, from the Dana-Farber Cancer Institute and ...
Journal of Clinical Investigation
