Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is ...
Journal of Clinical Investigation
A metabolic approach for retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous genetic disorder that is characterized by a progressive loss of photoreceptors that results in deterioration of vision.
Journal of Clinical Investigation
Characterizing the cells that underlie breast cancer recurrence
One of the leading factors in breast cancer-related death, is tumor recurrence despite apparently successful therapeutic intervention. Recurrent disease is linked ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Charles Sawyers
Charles Sawyers of Memorial Sloan Kettering Cancer Center has defined the molecular lesions that cause cancer and used these insights to develop new drugs ...
Journal of Clinical Investigation
Vaccine targeting protects macaques against vaginal infection
In this episode, Ma Luo and colleagues discuss how the anti-PCS T cell responses and the immune environment induced by the PCS vaccine are key correlates ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Huda Zoghbi
Dr. Huda Zoghbi is a pediatric neurologist, a Howard Hughes Medical Institute investigator; a professor in the departments of Pediatrics, Molecular and Human ...
Journal of Clinical Investigation
Enhanced mitochondrial fusion suppresses pancreatic cancer
In this episode, Cullen Taniguchi, Meifang Yu, Nicholas Nguyen, and colleagues demonstrate that enhancing mitochondrial fusion in pancreatic cancer cells ...
Journal of Clinical Investigation
JAK inhibitor treatment shows benefit for patients with interferonopathies
Patients with IFN-mediated autoinflammatory diseases, such as CANDLE and SAVI, present with a variety of severe manifestations, including fever and ...
Journal of Clinical Investigation
Naturally occurring cone disorder in nonhuman primates
Achromatopsia is form of congenital retinal degeneration characterized by the loss of cone photoreceptor function, resulting in dramatic loss of visual acuity.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Kornfeld
Dr. Stuart Kornfeld is the David C. and Betty Farrell Distinguished Professor of Medicine at Washington University in St. Louis. He is best known for his work ...
Journal of Clinical Investigation
Compound delivers a one-two punch to target cancer metabolism
Cancer cells have a different response to nutrient limitation than healthy cells; therefore, targeting nutrient acquisition pathways has potential as a therapeutic ...
Journal of Clinical Investigation
Increased atrial fibrillation in diabetic mice by distinct mechanisms
In this episode, Olurotimi O. Mesubi explains that the discovery of oxidation of CaMKII and O-GlcNAcylation differentially increased atrial fibrillation risk in type 1 ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Craig Thompson
Craig Thompson, MD, president and CEO of Memorial Sloan Kettering Cancer Center, has made fundamental contributions to our understanding of how cells ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Helen Hobbs
Helen Hobbs is an investigator of the Howard Hughes Medical Institute and a professor of Internal Medicine and Molecular Genetics at the University of Texas ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bonnie Bassler
Bonnie Bassler of Princeton University and the Howard Hughes Medical Institute has revolutionized the way that we think about microbiology. She elucidated ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Laurie Glimcher
Laurie Glimcher is a world-class immunologist who discovered the master transcription factors that direct immune cells to commit and activate. She has also ...
Journal of Clinical Investigation
Strain aneuploidy underlies fluconazole resistance in human cryptococcal meningitis
Cryptococcal meningitis (CM) is an opportunistic fungal infection that primarily affects immunocompromised individuals, particularly those with HIV/AIDS.
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells...- Christina E. Zielinski and Julia Matthias(TranslaTUM)
JCI- The Journal of clinical Investigation Authors's Take A personal perspective on new research in the JCI Topic: Salt generates antiinflammatory Th17 cells but ...
TranslaTUM
Tie1 deficiency limits cancer progression and metastasis
As primary tumor progression to metastasis dramatically increases mortality in patients with cancer, strategies to limit tumor cell growth and spread are of great ...
Journal of Clinical Investigation
Pancreatic cancer properties describe gemcitabine response
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadly forms of cancer, primarily due to the resistance of PDAC tumors to current therapeutic ...
Journal of Clinical Investigation
Intracranial hemorrhage development in fetal and neonatal alloimmune thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and ...
Journal of Clinical Investigation
Clinical trial of IL-7 in septic patients
Sepsis is a life-threatening complication of infection that results in over 250000 deaths per year in the United States. There is a strong correlation between ...
Journal of Clinical Investigation
Epigenetic targeting improves metabolic defects in obesity-prone mice
Obesity, diabetes, and other metabolic diseases have known underlying genetic causes; however, environmental factors also play an important role in the onset ...
Journal of Clinical Investigation
Targeting estrogen receptors to prevent binge eating
Binge eating is associated with obesity and depression. This disorder is more prevalent in women, and there is an apparent correlation between low estrogen ...
Journal of Clinical Investigation
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Helene Benveniste of Stony Brook University discusses the use of contrast-enhanced MRI to visualize the glymphatic system, a paravascular pathway that ...
Journal of Clinical Investigation
Fibronectin variant mediates smooth muscle cell phenotypic switching
In this episode, Anil Chauhan, Manish Jain, and colleagues reveal that smooth muscle cell- specific fibronectin containing an extra domain A mediates ...
Journal of Clinical Investigation
Exploring presenilin-1-associated familial Alzheimer's disease
Familial Alzheimer's disease (FAD) is an early on-set, hereditary form of neurological disease with variable pathophysiology that is often associated with loss of ...
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Paul Marks
Paul Marks is recognized as a leader in the cancer field and as a world-class scientist, clinician, and administrator. He served as president and CEO of Memorial ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
Sphingolipid desaturase DEGS1 linked to rare leukodystrophy
Leukodystrophies are rare congenital disorders that affect the white matter of the brain, resulting in a range of neurological presentations. Several ...
Journal of Clinical Investigation
Neuroflux sheds light on olfactory sensory neurons
PET allows noninvasive visualization of several physiological, neurochemical, and pharmacological processes within patients. Application of PET in the brain ...
Journal of Clinical Investigation
JCI's Conversation with Giants in Medicine: Jean Wilson
Dr. Jean Wilson from the University of Texas Southwestern Medical School joins the JCI for its series Conversations with Giants in Medicine. Dr. Wilson was the ...
Journal of Clinical Investigation
Broadly neutralizing HIV-1 antibody identified in a lupus patient
Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved ...
Journal of Clinical Investigation
Clinical Trials Medical Device & Drug Development Education Planning Session
We will also provide you with current options for financial assistance, career planning resources, and supply you with the courses within our Clinical Trials ...
UCI Division of Continuing Education
New Strategies for Clinical Trials in Autism Spectrum Disorder
New Strategies for Clinical Trials in Autism Spectrum Disorder Web: https://www.eurekaselect.com/188213/article Author(s): Rini Pauly, Catherine A. Ziats, ...
Bentham Science
Using proteomics to predict heart disease risk
Atherosclerosis can result in severe outcomes, including heart attack and stroke. The presence of atherosclerotic plaques is one of the first signs of disease; ...
Journal of Clinical Investigation
Vaginal epithelial shedding mediates ascending group B streptococcus infection
Group B streptococcus (GBS) is part of the normal vaginal flora of approximately 25% of healthy women. Unfortunately, GBS is associated with adverse ...
Journal of Clinical Investigation
Dr. Frank Harrell "Ways to Make Randomized Clinical Trials More Statistically Efficient" 10.23.20
Frank Harrell, PhD Department of Biostatistics Vanderbilt University School of Medicine Nashville TN USA.
UCLA Cardiology Fellowship
