JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Intracranial hemorrhage development in fetal and neonatal alloimmune thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Kornfeld
Dr. Stuart Kornfeld is the David C. and Betty Farrell Distinguished Professor of Medicine at Washington University in St. Louis. He is best known for his work ...
Journal of Clinical Investigation
Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Eugene Braunwald
Dr. Eugene Braunwald has often been called the father of modern cardiology. Science Watch has listed Dr. Braunwald as the most frequently cited author in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: David Nathan
David Nathan, professor at Harvard Medical School and President Emeritus of the Dana-Farber Cancer Institute, is a renowned hematologist with contributions ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Huda Zoghbi
Dr. Huda Zoghbi is a pediatric neurologist, a Howard Hughes Medical Institute investigator; a professor in the departments of Pediatrics, Molecular and Human ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Creating and publishing a scientific masterpiece
JCI Editor at Large Ushma S. Neill provides updated advice on generating a scientific manuscript with maximum impact.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
Стимуляция поясного пучка при операции на мозге в состоянии бодрствования
Credits: Kelly Bjanki et al. / The Journal of Clinical Investigation, 2019.
Nplus1
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Real-time imaging of intestinal lacteals
Kibaek Choe, Jeon Yeob Jang, Intae Park and colleagues visualize lipid drainage through lacteals using intravital, video-rate microscopy. The first video shows ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Francis Collins
After Francis Collins received his PhD in Physical Chemistry at Yale University and his medical degree at the University of North Carolina, he zeroed in on ...
Journal of Clinical Investigation
JCI Author's Take: Linking dietary sphingolipids to inflammation and intestinal carcinogenesis
Many lines of evidence support a link between prolonged inflammation and tumorigenic transformation. For example, patients with inflammatory bowel disease ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
A metabolic approach for retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous genetic disorder that is characterized by a progressive loss of photoreceptors that results in deterioration of vision.
Journal of Clinical Investigation
Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function.
Journal of Clinical Investigation
CD8+ T cell function may predict type 1 diabetes progression
In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Don Ganem
After a 15-year focus on the biology of the hepatitis B virus (HBV) family, the modern-day microbe hunter Don Ganem turned his attention to KSHV, the herpes ...
Journal of Clinical Investigation
p21 contributes to macrophage switching during sepsis
During sepsis, there is a progression from a hyperactive immune response to an immunosuppressive state that is characterized by macrophage reprogramming.
Journal of Clinical Investigation
2020 AAP Presidential Address: Mary E. Klotman, MD
A video version of an article published in the Journal of Clinical Investigation, "2020 Association of American Physicians Presidential Address: Call to arms ...
Journal of Clinical Investigation
Identification and characterization of GDF6 as a driver of melanoma
Melanoma-directed immunotherapies have improved quality of life and outcome for many patients with this malignancy. Unfortunately, treatment resistance ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
T cell transmigration through endothelial monolayer
The accompanying movie shows that WT T cells (video 1) are able to transmigrate through an endothelial monolayer, as indicated by the change in phase ...
Journal of Clinical Investigation
Vascular adhesion protein-1 and liver disease progression
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with metabolic dysfunction. Persistent hepatic inflammation in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Aaron Ciechanover
For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA.
Journal of Clinical Investigation
OX40 signals death for liver-resident immune cells
Invariant natural killer T (iNKT) cells are a prominent component of the liver-resident immune cell population. These cells are involved in both liver regeneration ...
Journal of Clinical Investigation
CD163+ macrophages serve pathogenic role in atherosclerosis
Macrophage polarization in response to stimuli within the microenvironment results in heterogeneous populations that can differentially influence disease.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Lloyd Hollingsworth Smith Jr.
Known to most of his friends as Holly, Dr. Lloyd Hollingsworth Smith Jr. joins Ushma Neill, JCI Editor at Large, for the next in the journal's series Conversations ...
Journal of Clinical Investigation
Human breast milk-derived commensal limits pathogenic inflammation
Necrotizing enterocolitis is a leading cause of death in preterm infants and is characterized by severe inflammation. The incidence of necrotizing enterocolitis is ...
Journal of Clinical Investigation
Immune tolerance-like pathway inhibits repair following white matter injury
White matter injury is associated with neurological dysfunction in a variety of conditions, ranging from cerebral palsy to vascular dementia. Oligodendrocyte ...
Journal of Clinical Investigation
Journal of Clinical Investigation - Medical Meaning and Pronunciation
https://www.amazon.com/Mosbys-Medical-Dictionary-Mosby/dp/0323414257?&_encoding=UTF8&tag=maturecolors2-20 Journal of Clinical Investigation ...
Medical Dictionary
Erythrocyte-derived microvesicles induce arterial spasms
In this Episode, Johanne Poisson, Marion Tanguy, Pierre-Emmanuel Rautou, and colleagues discuss that the high prevalence of myocardial infarction without ...
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
Unraveling profibrotic pathways in the kidney
Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation ...
Journal of Clinical Investigation
Poly(A)-specific ribonuclease deficiency in patients with dyskeratosis congenita
The inherited disorder dyskeratosis congenita is characterized by short telomeres, mucocutaneous abnormalities, and bone marrow failure. The underlying ...
Journal of Clinical Investigation
Maintaining adult hematopoiesis
An inability to properly sustain blood cell production results in the development of hematopoietic disorders. Epigenetic regulators have been shown to be ...
Journal of Clinical Investigation
Breaking down skin barrier function in mice with pruritic dermatitis
maintained through constant proliferation and differentiation of epidermal cells. However, the mechanisms that regulate skin homeostasis are not fully ...
Journal of Clinical Investigation
Murine model of autism-like syndrome benefits from NAP treatment
Activity-dependent neuroprotective protein (ADNP) is essential for brain formation, and mutations in the ADNP-encoding gene have been linked to an ...
Journal of Clinical Investigation
