Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Francis Collins
After Francis Collins received his PhD in Physical Chemistry at Yale University and his medical degree at the University of North Carolina, he zeroed in on ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Marc Feldmann, Jacques Miller, and Max Cooper
Sir Marc Feldmann, Lasker awardee in 2003 for his role in discovering anti-TNF therapy, acts as interviewer, speaking with the two recipients of the 2019 Albert ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Michael Hall
Michael N. Hall was recently announced as the recipient of the 2017 Albert Lasker Basic Medical Research Award for the discovery of TOR proteins, which play ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Huda Zoghbi
Dr. Huda Zoghbi is a pediatric neurologist, a Howard Hughes Medical Institute investigator; a professor in the departments of Pediatrics, Molecular and Human ...
Journal of Clinical Investigation
Tie1 deficiency limits cancer progression and metastasis
As primary tumor progression to metastasis dramatically increases mortality in patients with cancer, strategies to limit tumor cell growth and spread are of great ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Kornfeld
Dr. Stuart Kornfeld is the David C. and Betty Farrell Distinguished Professor of Medicine at Washington University in St. Louis. He is best known for his work ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Spiegelman
More than almost any other scientist in the field of obesity and metabolism research, the work of Bruce Spiegelman, from the Dana-Farber Cancer Institute and ...
Journal of Clinical Investigation
JCI Author's Take: Linking dietary sphingolipids to inflammation and intestinal carcinogenesis
Many lines of evidence support a link between prolonged inflammation and tumorigenic transformation. For example, patients with inflammatory bowel disease ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Eugene Braunwald
Dr. Eugene Braunwald has often been called the father of modern cardiology. Science Watch has listed Dr. Braunwald as the most frequently cited author in ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
The TGR5 receptor mediates bile acid-induced itch and analgesia
The liver secretes bile acids to aid in the digestion of fats. Cholestasis is a condition in which the bile flow from the liver to the duodenum is impeded. Patients ...
Journal of Clinical Investigation
Adoptive transfer of EBV-specific T cells in patients with multiple sclerosis
Multiple sclerosis (MS) is a chronic inflammatory disease of the CNS characterized by progressive demyelination and disability. Epstein-Barr (EBV) virus has ...
Journal of Clinical Investigation
Poly(A)-specific ribonuclease deficiency in patients with dyskeratosis congenita
The inherited disorder dyskeratosis congenita is characterized by short telomeres, mucocutaneous abnormalities, and bone marrow failure. The underlying ...
Journal of Clinical Investigation
CD163+ macrophages serve pathogenic role in atherosclerosis
Macrophage polarization in response to stimuli within the microenvironment results in heterogeneous populations that can differentially influence disease.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
Broadly neutralizing HIV-1 antibody identified in a lupus patient
Broadly neutralizing antibodies (BnAbs) represent a promising strategy for targeting rapidly mutating viruses, such as HIV-1. BnAbs recognize conserved ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Don Ganem
After a 15-year focus on the biology of the hepatitis B virus (HBV) family, the modern-day microbe hunter Don Ganem turned his attention to KSHV, the herpes ...
Journal of Clinical Investigation
Kisspeptin in the limbic system
The hormone kisspeptin is essential for reproductive function, an effect that is mediated by its actions in the hypothalamus. Recent studies suggest that ...
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Christine Seidman
Dr. Christine Seidman of the Harvard Medical School has uncovered the genetic basis of many human cardiovascular disorders, from cardiomyopathy and heart ...
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Twenty-six compelling conversations
Since May 2012, the JCI has aired twenty-six interviews with twenty-eight notable scientists for the series Conversations with Giants in Medicine. In the highlight ...
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
Urinary markers of acute interstitial nephritis
In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis…
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Aaron Ciechanover
For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA.
Journal of Clinical Investigation
Erythrocyte-derived microvesicles induce arterial spasms
In this Episode, Johanne Poisson, Marion Tanguy, Pierre-Emmanuel Rautou, and colleagues discuss that the high prevalence of myocardial infarction without ...
Journal of Clinical Investigation
UK Study Finds Potential New Drug Target for Lung Cancer
Led by University of Kentucky Markey Cancer Center researcher Teresa Fan and published in the Journal of Clinical Investigation, a new study suggests that ...
University of Kentucky
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: David Nathan
David Nathan, professor at Harvard Medical School and President Emeritus of the Dana-Farber Cancer Institute, is a renowned hematologist with contributions ...
Journal of Clinical Investigation
Vascular adhesion protein-1 and liver disease progression
Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with metabolic dysfunction. Persistent hepatic inflammation in ...
Journal of Clinical Investigation
Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function.
Journal of Clinical Investigation
Identification and characterization of GDF6 as a driver of melanoma
Melanoma-directed immunotherapies have improved quality of life and outcome for many patients with this malignancy. Unfortunately, treatment resistance ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
