JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
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JCI's Conversation with Giants in Medicine: Donald Seldin
We are joined by Donald Seldin from The University of Texas Southwestern Medical School. Seldin served as the chairman of medicine at UT Southwestern for ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the ...
Journal of Clinical Investigation
What Is The Definition Of Journal of Clinical Investigation - Medical Dictionary Free Online Terms
Visit our website for text version of this Definition and app download. http://www.medicaldictionaryapps.com Subjects: medical terminology, medical dictionary, ...
Medical Dictionary Online
Journal of Clinical Investigation spanish MEANING
TOP LIST HERE: https://www.youtube.com/playlist?list=PLwTXvKHGHam46KJ_waPqG5PPapwi4iz3K Simple Way for people who understand spanish, to know ...
TOP SPANISH BEST EXPLAINED LEVEL 10
Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Elaine Fuchs
Cell biologist Elaine Fuchs of the Rockefeller University is best known for revolutionizing the molecular and genetic study of skin. Her research has shed light on ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
Patient Oriented Care in the Medical Sciences in Clinical Investigation Program
Finnian Mc Causland, MBBCh, MMSc, FRCPI, PG CertMedEd, Co-Director of the Master of Medical Sciences in Clinical Investigation (MMSCI) program ...
Harvard Medical School
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the ...
Journal of Clinical Investigation
Blazing the trail for metastasis
The accompanying movie shows the invasion dynamics of breast cancer spheroids in organotypic culture. Spheroids are composed of trailblazer cells, ...
Journal of Clinical Investigation
Macrophages activate ovarian tumor cell proliferation and migration during metastasis
During transcoelomic metastasis, ovarian tumor cells detach from the primary tumor site and migrate to the peritoneal cavity, where their survival is supported by ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stephen O'Rahilly
Professor Stephen O'Rahilly's research has led to an increased understanding of the genetic causes of human obesity and insulin resistance. Using modern ...
Journal of Clinical Investigation
A metabolic approach for retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous genetic disorder that is characterized by a progressive loss of photoreceptors that results in deterioration of vision.
Journal of Clinical Investigation
Characterizing the cells that underlie breast cancer recurrence
One of the leading factors in breast cancer-related death, is tumor recurrence despite apparently successful therapeutic intervention. Recurrent disease is linked ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by ...
Journal of Clinical Investigation
Qualitative Research for Public Health and Clinical Investigation
This video is a one-hour lecture that Roberta E. Goldman, PHD delivered as part of the Harvard Catalyst lecture series in 2011. The lecture presents an overview ...
Brown University
JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
CD163+ macrophages serve pathogenic role in atherosclerosis
Macrophage polarization in response to stimuli within the microenvironment results in heterogeneous populations that can differentially influence disease.
Journal of Clinical Investigation
Altered abiraterone metabolism in individuals with HSD3B1 variant
Prostate cancer is driven by stimulation of the androgen receptor (AR) with testosterone and the potent metabolite 5α-dihydrotestosterone (DHT); therefore, ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Neuropeptide FF acts on adipose tissue macrophages
The accumulation of macrophages with a proinflammatory phenotype in adipose tissue is a driver of obesity-associated metabolic disease. While adipose tissue ...
Journal of Clinical Investigation
Intracranial hemorrhage development in fetal and neonatal alloimmune thrombocytopenia
Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is a life-threatening condition that results from the development of maternal antibodies that target and ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
Isoquercetin reduces coagulation markers in patients at risk of thrombosis
The release of protein disulfide isomerase (PDI) from cells during disease or in response to injury can exacerbate pathological processes, including ...
Journal of Clinical Investigation
CBD's War on Zits
In this video Dr. Barry reviews a study that reveals the potential CBD has on the effects of acne. https://cbdproonline.com/cbds-war-on-zits/ Just about everyone ...
Dr. Barry Morrison
La marihuana es la única droga capaz de regenerar células nerviosas
Una investigación publicada en 2005 por The Journal of Clinical Investigation concluyó que el cannabis es la única droga ilícita que estimula el crecimiento de ...
Luis Vásquez
Vaginal epithelial shedding mediates ascending group B streptococcus infection
Group B streptococcus (GBS) is part of the normal vaginal flora of approximately 25% of healthy women. Unfortunately, GBS is associated with adverse ...
Journal of Clinical Investigation
Nieuwe Noorse studie naar de pathologische mechanismen bij ME (2017)
Een nieuwe studie van Drs. Fluge en Mella stelt dat het PDH-enzym geremd wordt bij ME-patiënten, wat zowel het energietekort als de verhoogde ...
ME/cvs Vereniging
C5a impairs phagosomal maturation through phosphoproteomic remodeling
C5a disrupts the neutrophil phosphoproteomic response to bacteria, impairing phagosomal maturation and bacterial killing.
Journal of Clinical Investigation
REG3α as a biomarker and therapeutic target for GVHD
Graft-versus-host-disease (GVHD) is a life-threatening complication of allogeneic BM transplantation that affects skin, liver, and the gastrointestinal (GI) tract.
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
Neuroflux sheds light on olfactory sensory neurons
PET allows noninvasive visualization of several physiological, neurochemical, and pharmacological processes within patients. Application of PET in the brain ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Beutler
A legend within the field of innate immunity, Dr. Bruce Beutler of the University of Texas Southwestern Medical School is best known for two seminal discoveries: ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
Addressing the point of no return for gene therapy
Retinitis pigmentosa (RP) is hereditary retinal degenerative disease that is characterized by progressive loss of photoreceptor function. In human trials, gene ...
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
Urinary markers of acute interstitial nephritis
In this episode, Chirag Parikh and colleagues demonstrate that urine TNF-α and IL-9 levels improve prebiopsy diagnosis of acute interstitial nephritis…
Journal of Clinical Investigation
