JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Charles Sawyers
Charles Sawyers of Memorial Sloan Kettering Cancer Center has defined the molecular lesions that cause cancer and used these insights to develop new drugs ...
Journal of Clinical Investigation
Creating and publishing a scientific masterpiece
JCI Editor at Large Ushma S. Neill provides updated advice on generating a scientific manuscript with maximum impact.
Journal of Clinical Investigation
Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
Centre for Clinical Investigation and Therapeutics (CCIT)
Centre for Clinical Investigation and Therapeutics (CCIT)
LHSFCanada
The Clinical Investigation Plan
Course Description: Provides the basic information on roles and responsibilities within the process of writing a clinical investigation plan as well as tools for the ...
WMDO
Journal of Clinical Investigation spanish MEANING
TOP LIST HERE: https://www.youtube.com/playlist?list=PLwTXvKHGHam46KJ_waPqG5PPapwi4iz3K Simple Way for people who understand spanish, to know ...
TOP SPANISH BEST EXPLAINED LEVEL 10
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
Strain aneuploidy underlies fluconazole resistance in human cryptococcal meningitis
Cryptococcal meningitis (CM) is an opportunistic fungal infection that primarily affects immunocompromised individuals, particularly those with HIV/AIDS.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Twenty Fascinating Conversations
Since 2012 JCI Editor at Large Ushma Neill has interviewed scientists as part of the Conversations with Giants in Medicine series, including Laurie Glimcher, ...
Journal of Clinical Investigation
The TGR5 receptor mediates bile acid-induced itch and analgesia
The liver secretes bile acids to aid in the digestion of fats. Cholestasis is a condition in which the bile flow from the liver to the duodenum is impeded. Patients ...
Journal of Clinical Investigation
RSM COVID-19 Series | Episode 24: Medical Journals
Recorded on Tuesday 23 June 2020 as part of the Royal Society of Medicine's COVID-19 Series. In this episode, Professor Sir Simon Wessely spoke to Dr ...
Royal Society of Medicine
Qualitative Research for Public Health and Clinical Investigation
This video is a one-hour lecture that Roberta E. Goldman, PHD delivered as part of the Harvard Catalyst lecture series in 2011. The lecture presents an overview ...
Brown University
Compound delivers a one-two punch to target cancer metabolism
Cancer cells have a different response to nutrient limitation than healthy cells; therefore, targeting nutrient acquisition pathways has potential as a therapeutic ...
Journal of Clinical Investigation
Using proteomics to predict heart disease risk
Atherosclerosis can result in severe outcomes, including heart attack and stroke. The presence of atherosclerotic plaques is one of the first signs of disease; ...
Journal of Clinical Investigation
Naturally occurring cone disorder in nonhuman primates
Achromatopsia is form of congenital retinal degeneration characterized by the loss of cone photoreceptor function, resulting in dramatic loss of visual acuity.
Journal of Clinical Investigation
Deimination restores inner retinal visual function in murine demyelinating disease
Sanjoy Bhattarcharya and Vittorio Porciatti of the University of Miami discuss the role of deimination, a post-translational protein modification, in retinal function.
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: George Church
The geneticist, innovator, and entrepreneur George Church, of Harvard and MIT, developed the methods for the first genome sequencing, and his subsequent ...
Journal of Clinical Investigation
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is ...
Journal of Clinical Investigation
A biomarker signature of treatment-resistant HPV-related cancer
Human papilloma virus (HPV) is an etiological agent of oropharyngeal squamous cell carcinoma (OPSCC). Patients with HPV+ OPSCC have high long-term ...
Journal of Clinical Investigation
Examining the role of cullin 3 in hyperkalemic hypertension
Familial hyperkalemic hypertension (FHHt) is a rare monogenic disease that results from mutations in the kinases WNK1 and WNK4 or mutations in the ubiquitin ...
Journal of Clinical Investigation
Addressing the point of no return for gene therapy
Retinitis pigmentosa (RP) is hereditary retinal degenerative disease that is characterized by progressive loss of photoreceptor function. In human trials, gene ...
Journal of Clinical Investigation
David Fox, MD - Video Profile
Professor, Internal Medicine Specialties: Rheumatology, Internal Medicine Clinical Interests: Rheumatoid arthritis and systemic lupus erythematosus A member ...
Michigan Medicine
CD8+ T cell function may predict type 1 diabetes progression
In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive ...
Journal of Clinical Investigation
[Research Highlights] Mast cell engagement of gamma delta T cells protects against viral infection
The skin is an important barrier to infections and contains resident immune cells poised to respond to pathogens. Tissue-resident mast cells are critical for ...
Duke-NUS
JCI's Conversations with Giants in Medicine: Aaron Ciechanover
For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Don Ganem
After a 15-year focus on the biology of the hepatitis B virus (HBV) family, the modern-day microbe hunter Don Ganem turned his attention to KSHV, the herpes ...
Journal of Clinical Investigation
Non-classical monocytes contribute to treatment resistance against anti-VEGF cancer therapies
Jung et al. describe how immunosuppressive effects of non-classical Ly6C-low monocytes contribute to resistance against anti-VEGF therapies in mouse ...
Journal of Clinical Investigation
CXCR5+ T helper cells mediate protective immunity against tuberculosis
Shabaana Khader of the University of Pittsburgh discusses the identification of immune parameters that distinguish active and latent TB infections. • One third of ...
Journal of Clinical Investigation
Dynamic focal adhesions
The accompanying movie shows the effect of targeting different genes on focal adhesion dynamics, which are essential for cell migration. Control and ...
Journal of Clinical Investigation
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular ...
Journal of Clinical Investigation
Human breast milk-derived commensal limits pathogenic inflammation
Necrotizing enterocolitis is a leading cause of death in preterm infants and is characterized by severe inflammation. The incidence of necrotizing enterocolitis is ...
Journal of Clinical Investigation
Improving metabolism prolongs cone cell survival
Retinitis pigmentosa (RP) is an inherited degenerative eye disease that results from the presence of mutations in rod-associated genes. Cone cells, which ...
Journal of Clinical Investigation
Composite signature for prediction of T1D progression
In this episode, Cate Speake and colleagues employ an analytical method that incorporates reproducibility testing to identify a composite signature prognostic ...
Journal of Clinical Investigation
Local TNF mediates free cholesterol–dependent podocyte injury
Some patients with diabetes develop diabetic kidney disease (DKD), which can progress to a loss of renal function. High levels of TNF are predictive of disease ...
Journal of Clinical Investigation
Targeting estrogen receptors to prevent binge eating
Binge eating is associated with obesity and depression. This disorder is more prevalent in women, and there is an apparent correlation between low estrogen ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
Increased brain uptake and oxidation of acetate in heavy drinkers
Graeme Mason of Yale University discusses how heavy drinking influences metabolism and leads to alternate fuel use in the brain. Highlights: • Brain acetate ...
Journal of Clinical Investigation
p21 contributes to macrophage switching during sepsis
During sepsis, there is a progression from a hyperactive immune response to an immunosuppressive state that is characterized by macrophage reprogramming.
Journal of Clinical Investigation
Complement receptor C3aR1-mediated protection in spinal cord injury
In this episode, Marc Ruitenberg and colleagues demonstrate that complement receptor C3aR stimulates PTEN to inhibit neutrophil-mediated inflammatory ...
Journal of Clinical Investigation
Altered abiraterone metabolism in individuals with HSD3B1 variant
Prostate cancer is driven by stimulation of the androgen receptor (AR) with testosterone and the potent metabolite 5α-dihydrotestosterone (DHT); therefore, ...
Journal of Clinical Investigation
IL-36γ induction underlies EGFR inhibitor-associated skin toxicity
In this episode, Lars French, Takashi K. Satoh and colleagues show that EGFR/MEK inhibitors and the commensal Cutibacterium acnes synergistically induce ...
Journal of Clinical Investigation
