JCI's Conversations with Giants in Medicine: Jesse Roth
We take it for granted today that each hormone and other intercellular messenger have their own specific receptors. But this was not the case until the ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
Strain aneuploidy underlies fluconazole resistance in human cryptococcal meningitis
Cryptococcal meningitis (CM) is an opportunistic fungal infection that primarily affects immunocompromised individuals, particularly those with HIV/AIDS.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Twenty Fascinating Conversations
Since 2012 JCI Editor at Large Ushma Neill has interviewed scientists as part of the Conversations with Giants in Medicine series, including Laurie Glimcher, ...
Journal of Clinical Investigation
The TGR5 receptor mediates bile acid-induced itch and analgesia
The liver secretes bile acids to aid in the digestion of fats. Cholestasis is a condition in which the bile flow from the liver to the duodenum is impeded. Patients ...
Journal of Clinical Investigation
David Fox, MD - Video Profile
Professor, Internal Medicine Specialties: Rheumatology, Internal Medicine Clinical Interests: Rheumatoid arthritis and systemic lupus erythematosus A member ...
Michigan Medicine
Beige Area Detection Software : Journal of Clinical Investigation : JCI 125646
This Software is published as a part of research article https://www.jci.org/articles/view/125646 in Journal of Clinical Investigation title: Breast milk alkylglycerols ...
Gopal Karemore
[Research Highlights] Mast cell engagement of gamma delta T cells protects against viral infection
The skin is an important barrier to infections and contains resident immune cells poised to respond to pathogens. Tissue-resident mast cells are critical for ...
Duke-NUS
Mayo Clinic Minute 07.23.2015
Mayo Clinic Minute 07.23.2015 *video courtesy of: Journal of Clinical Investigation.
Mayo Clinic
Brain-wide pathway for waste clearance captured by contrast-enhanced MRI
Helene Benveniste of Stony Brook University discusses the use of contrast-enhanced MRI to visualize the glymphatic system, a paravascular pathway that ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
Using proteomics to predict heart disease risk
Atherosclerosis can result in severe outcomes, including heart attack and stroke. The presence of atherosclerotic plaques is one of the first signs of disease; ...
Journal of Clinical Investigation
Identification of weight loss-mediating liraglutide targets
The type 2 diabetes drug liraglutide is a glucagon-like peptide-1 receptor (GLP-1R) agonist that lowers blood glucose and reduces body weight. Liraglutide is ...
Journal of Clinical Investigation
RSM COVID-19 Series | Episode 24: Medical Journals
Recorded on Tuesday 23 June 2020 as part of the Royal Society of Medicine's COVID-19 Series. In this episode, Professor Sir Simon Wessely spoke to Dr ...
Royal Society of Medicine
Compound delivers a one-two punch to target cancer metabolism
Cancer cells have a different response to nutrient limitation than healthy cells; therefore, targeting nutrient acquisition pathways has potential as a therapeutic ...
Journal of Clinical Investigation
Diabetes-associated genetic variation alters insulin secretion
In this Episode, Adrian Vella and colleagues discuss abnormal insulin pulse characteristics in non-diabetic individuals are linked with diabetes-associated ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Addressing the point of no return for gene therapy
Retinitis pigmentosa (RP) is hereditary retinal degenerative disease that is characterized by progressive loss of photoreceptor function. In human trials, gene ...
Journal of Clinical Investigation
CD8+ T cell function may predict type 1 diabetes progression
In this episode, Alice Long and colleagues demonstrate a link between disease outcome in type 1 diabetes and the phenotype and function of autoreactive ...
Journal of Clinical Investigation
Examining the role of cullin 3 in hyperkalemic hypertension
Familial hyperkalemic hypertension (FHHt) is a rare monogenic disease that results from mutations in the kinases WNK1 and WNK4 or mutations in the ubiquitin ...
Journal of Clinical Investigation
Non-classical monocytes contribute to treatment resistance against anti-VEGF cancer therapies
Jung et al. describe how immunosuppressive effects of non-classical Ly6C-low monocytes contribute to resistance against anti-VEGF therapies in mouse ...
Journal of Clinical Investigation
REG3α as a biomarker and therapeutic target for GVHD
Graft-versus-host-disease (GVHD) is a life-threatening complication of allogeneic BM transplantation that affects skin, liver, and the gastrointestinal (GI) tract.
Journal of Clinical Investigation
Human breast milk-derived commensal limits pathogenic inflammation
Necrotizing enterocolitis is a leading cause of death in preterm infants and is characterized by severe inflammation. The incidence of necrotizing enterocolitis is ...
Journal of Clinical Investigation
IL-36γ induction underlies EGFR inhibitor-associated skin toxicity
In this episode, Lars French, Takashi K. Satoh and colleagues show that EGFR/MEK inhibitors and the commensal Cutibacterium acnes synergistically induce ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Aaron Ciechanover
For decades, the attention of the scientific community was focused on the central dogma of biology — the decoding of the genetic information embedded in DNA.
Journal of Clinical Investigation
Composite signature for prediction of T1D progression
In this episode, Cate Speake and colleagues employ an analytical method that incorporates reproducibility testing to identify a composite signature prognostic ...
Journal of Clinical Investigation
Protecting the kidney through ion channel inhibition
Damage to the glomerulus, which mediates the kidney's filtering function, causes plasma protein to spill into the urine, a sign of kidney failure and cardiovascular ...
Journal of Clinical Investigation
Altered abiraterone metabolism in individuals with HSD3B1 variant
Prostate cancer is driven by stimulation of the androgen receptor (AR) with testosterone and the potent metabolite 5α-dihydrotestosterone (DHT); therefore, ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
Increased brain uptake and oxidation of acetate in heavy drinkers
Graeme Mason of Yale University discusses how heavy drinking influences metabolism and leads to alternate fuel use in the brain. Highlights: • Brain acetate ...
Journal of Clinical Investigation
Improving metabolism prolongs cone cell survival
Retinitis pigmentosa (RP) is an inherited degenerative eye disease that results from the presence of mutations in rod-associated genes. Cone cells, which ...
Journal of Clinical Investigation
Local TNF mediates free cholesterol–dependent podocyte injury
Some patients with diabetes develop diabetic kidney disease (DKD), which can progress to a loss of renal function. High levels of TNF are predictive of disease ...
Journal of Clinical Investigation
Targeting estrogen receptors to prevent binge eating
Binge eating is associated with obesity and depression. This disorder is more prevalent in women, and there is an apparent correlation between low estrogen ...
Journal of Clinical Investigation
Real-time imaging of intestinal lacteals
Kibaek Choe, Jeon Yeob Jang, Intae Park and colleagues visualize lipid drainage through lacteals using intravital, video-rate microscopy. The first video shows ...
Journal of Clinical Investigation
p21 contributes to macrophage switching during sepsis
During sepsis, there is a progression from a hyperactive immune response to an immunosuppressive state that is characterized by macrophage reprogramming.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: James Rothman
In the 1970s and '80s, James Rothman of Yale University bucked all advice on how to do scientific experiments and broke open cells in order to study the way ...
Journal of Clinical Investigation
TSC–associated cystic kidney disease is prevented in pregnancy
In this episode, Oded Volovelsky and colleagues report that rapamycin or dexamethasone administration in pregnancy to a mouse model of tuberous sclerosis ...
Journal of Clinical Investigation
Complement receptor C3aR1-mediated protection in spinal cord injury
In this episode, Marc Ruitenberg and colleagues demonstrate that complement receptor C3aR stimulates PTEN to inhibit neutrophil-mediated inflammatory ...
Journal of Clinical Investigation
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis
Jane Salmon, Carl Blobel, Priya Darshinee Issuree, and Thorsten Maretzky of the Weill Cornell University Hospital for Special Surgery discuss the role of ...
Journal of Clinical Investigation
PSD-95 expression controls L-DOPA dyskinesia through dopamine D1 receptor trafficking
Erwan Bezard and Laurent Groc of the University of Bordeaux discuss the effects of the post-synaptic density protein PSD-95 on the development of ...
Journal of Clinical Investigation
S100A8/A9 regulates during chronic tuberculosis
In this episode, Shabaana Khader and Rosemary Swanson discuss how the alarmin S100A8/A9 mediates neutrophil accumulation during progression to ...
Journal of Clinical Investigation
Evaluation of kisspeptin-54 for egg maturation
In virto fertilization (IVF) has helped millions of couples facing infertility have children. While considered relatively safe, there are risks associated with this ...
Journal of Clinical Investigation
