mTOR-dependent translation amplifies microglia priming
In this episode, Melania Capasso explains how mTOR is hyperactivated in microglia with age and causes increased translation of inflammatory mediators, thus ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stuart Orkin
During Stuart Orkin's training as a physician-scientist, he decided to focus on pediatric blood disorders as an area where disease genetics could connect directly ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Eric Olson
Eric Olson's pivotal research in the field of molecular biology has uncovered the mechanisms that control cardiac and skeletal muscle development. His current ...
Journal of Clinical Investigation
JCI's Conversation with Giants in Medicine: Donald Seldin
We are joined by Donald Seldin from The University of Texas Southwestern Medical School. Seldin served as the chairman of medicine at UT Southwestern for ...
Journal of Clinical Investigation
Akademik Yayınları İndirmenin Basit Yolları
Akademik makaleleri indirmenin en basit yolları anlatılmıştır.
LisansüstüYardımcısı
Characterizing the cells that underlie breast cancer recurrence
One of the leading factors in breast cancer-related death, is tumor recurrence despite apparently successful therapeutic intervention. Recurrent disease is linked ...
Journal of Clinical Investigation
Journal of Clinical Investigation spanish MEANING
TOP LIST HERE: https://www.youtube.com/playlist?list=PLwTXvKHGHam46KJ_waPqG5PPapwi4iz3K Simple Way for people who understand spanish, to know ...
TOP SPANISH BEST EXPLAINED LEVEL 10
JCI’s Conversations with Giants in Medicine: C. Ronald Kahn
C. Ronald (Ron) Kahn of the Joslin Diabetes Center at Harvard Medical School is a physician-scientist who illuminated much of what we appreciate about the ...
Journal of Clinical Investigation
What Is The Definition Of Journal of Clinical Investigation - Medical Dictionary Free Online Terms
Visit our website for text version of this Definition and app download. http://www.medicaldictionaryapps.com Subjects: medical terminology, medical dictionary, ...
Medical Dictionary Online
Chilling out and firming up
Brown adipose tissue (BAT), which mediates non-shivering thermogenesis, contributes to whole body energy expenditure and weight regulation in rodents.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Elaine Fuchs
Cell biologist Elaine Fuchs of the Rockefeller University is best known for revolutionizing the molecular and genetic study of skin. Her research has shed light on ...
Journal of Clinical Investigation
Maternal B12 status influences offspring bone mass
The maternal environment not only affects in utero development, but also can dramatically influence postnatal phenotypes. In this episode, Vijay Yadav, Isabel ...
Journal of Clinical Investigation
Patient Oriented Care in the Medical Sciences in Clinical Investigation Program
Finnian Mc Causland, MBBCh, MMSc, FRCPI, PG CertMedEd, Co-Director of the Master of Medical Sciences in Clinical Investigation (MMSCI) program ...
Harvard Medical School
JCI's Conversations with Giants in Medicine: "Best Of"
JCI Editor at Large Ushma S. Neill's "best-of" clips from Conversations with Giants in Medicine, 2012-2017.
Journal of Clinical Investigation
Gs/Gq signaling switch in β cells underlies the potential of incretins in diabetes
In this episode, Susumu Seino and Okechi S. Oduori explain how persistent depolarization of β-cells leads to Gs to Gq signaling switch, explaining the ...
Journal of Clinical Investigation
Macrophages activate ovarian tumor cell proliferation and migration during metastasis
During transcoelomic metastasis, ovarian tumor cells detach from the primary tumor site and migrate to the peritoneal cavity, where their survival is supported by ...
Journal of Clinical Investigation
Blazing the trail for metastasis
The accompanying movie shows the invasion dynamics of breast cancer spheroids in organotypic culture. Spheroids are composed of trailblazer cells, ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Stephen O'Rahilly
Professor Stephen O'Rahilly's research has led to an increased understanding of the genetic causes of human obesity and insulin resistance. Using modern ...
Journal of Clinical Investigation
A metabolic approach for retinal degeneration
Retinitis pigmentosa (RP) is a heterogeneous genetic disorder that is characterized by a progressive loss of photoreceptors that results in deterioration of vision.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Barbara Kahn
Barbara Kahn is the quintessential physician-scientist. Dr. Kahn, of the Beth Israel Deaconess Medical Center and Harvard Medical School, is best known for ...
Journal of Clinical Investigation
Salt generates antiinflammatory Th17 cells but amplifies pathogenicity
In this episode, Christina Zielinski and Julia Matthias explain that sodium chloride generates anti-inflammatory human Th17 cell responses but is coopted by ...
Journal of Clinical Investigation
Battling cholangiocarcinoma with WNT inhibition
Cholangiocarcinoma is a cancer of the bile duct that has a poor prognosis, largely due to it being refractory to available therapies. In this episode, Stuart Forbes ...
Journal of Clinical Investigation
Neuroflux sheds light on olfactory sensory neurons
PET allows noninvasive visualization of several physiological, neurochemical, and pharmacological processes within patients. Application of PET in the brain ...
Journal of Clinical Investigation
Enteroendocrine cells connecting with neurons
The accompanying movie shows a purified enteroendocrine cell and trigeminal (TG) neuron making a connection (Video 1) and an enteroendocrine cell seeking ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Harold E. Varmus, MD
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: David Nathan
David Nathan, professor at Harvard Medical School and President Emeritus of the Dana-Farber Cancer Institute, is a renowned hematologist with contributions ...
Journal of Clinical Investigation
Insight into helminth-associated susceptibility to tuberculosis
The pulmonary disease tuberculosis (TB) is a global health problem that results from Mycobacterium tuberculosis (Mtb) infection. As parasitic helminth worms ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Thomas Starzl
Today in the United States, more than 6000 people a year receive a liver transplant, and since liver transplants have begun, over 200000 patients have received ...
Journal of Clinical Investigation
Altered abiraterone metabolism in individuals with HSD3B1 variant
Prostate cancer is driven by stimulation of the androgen receptor (AR) with testosterone and the potent metabolite 5α-dihydrotestosterone (DHT); therefore, ...
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Oliver Smithies
Oliver Smithies of the University of North Carolina at Chapel Hill was awarded the 2007 Nobel Prize in Physiology or Medicine for pioneering homologous ...
Journal of Clinical Investigation
Unraveling profibrotic pathways in the kidney
Fibrosis is a hallmark of chronic kidney disease that is characterized by accumulation of extracellular matrix and an influx of immune cells. Autophosphorylation ...
Journal of Clinical Investigation
Neuropeptide FF acts on adipose tissue macrophages
The accumulation of macrophages with a proinflammatory phenotype in adipose tissue is a driver of obesity-associated metabolic disease. While adipose tissue ...
Journal of Clinical Investigation
Vaginal epithelial shedding mediates ascending group B streptococcus infection
Group B streptococcus (GBS) is part of the normal vaginal flora of approximately 25% of healthy women. Unfortunately, GBS is associated with adverse ...
Journal of Clinical Investigation
Addressing the point of no return for gene therapy
Retinitis pigmentosa (RP) is hereditary retinal degenerative disease that is characterized by progressive loss of photoreceptor function. In human trials, gene ...
Journal of Clinical Investigation
Targeting estrogen receptors to prevent binge eating
Binge eating is associated with obesity and depression. This disorder is more prevalent in women, and there is an apparent correlation between low estrogen ...
Journal of Clinical Investigation
REG3α as a biomarker and therapeutic target for GVHD
Graft-versus-host-disease (GVHD) is a life-threatening complication of allogeneic BM transplantation that affects skin, liver, and the gastrointestinal (GI) tract.
Journal of Clinical Investigation
JCI's Conversations with Giants in Medicine: Bruce Beutler
A legend within the field of innate immunity, Dr. Bruce Beutler of the University of Texas Southwestern Medical School is best known for two seminal discoveries: ...
Journal of Clinical Investigation
Autophagy defends β cells from amyloid accumulation
β cell dysfunction is a hallmark of type 2 diabetes (T2D) and is associated with extracellular accumulation of amyloid plaques comprised of islet amyloid ...
Journal of Clinical Investigation
JCI’s Conversations with Giants in Medicine: Gregg Semenza
Gregg Semenza is a geneticist at Johns Hopkins University School of Medicine whose research has been recognized with multiple awards for advancements in ...
Journal of Clinical Investigation
Antioxidant gene delivery protects photoreceptors
The inherited form of blindness retinitis pigmentosa (RP) results in a progressive loss of photoreceptors. RP-associated mutations directly promote the death of ...
Journal of Clinical Investigation
Epigenetic alterations in stromal cells mediate prostate cancer phenotypes
Prostate cancer is an androgen-dependent disease; therefore, current approaches for treatment aim to disrupt androgen signaling. Unfortunately, this approach ...
Journal of Clinical Investigation
Identification and characterization of GDF6 as a driver of melanoma
Melanoma-directed immunotherapies have improved quality of life and outcome for many patients with this malignancy. Unfortunately, treatment resistance ...
Journal of Clinical Investigation
